{"product_id":"capillary-electrophoresis-of-carbohydrates-213-methods-in-molecular-biology","title":"Capillary Electrophoresis of Carbohydrates: 213 (Methods in Molecular Biology)","description":"Glycoconjugates such as glycoproteins and glycolipids play important roles in cell-cell interaction events, including development, differentiation, m- phogenesis, fertilization, inflammation, and metastasis. A number of reports have documented the association of unique oligosaccharide sequences to p- tein targeting and folding, and in mechanisms of infection, inflammation, and immunity. For glycoproteins, these glycan appendages are the result of extensive co- or post-translational modifications of the nascent proteins in the endoplasmic reticulum and in the Golgi apparatus. Although nucleic acids and proteins are copied from a template in a repeated series of identical steps using the same enzymes, complex carbohydrates are formed by the sequential actions of cellular glycosyltransferases that specifically recognize unique s- strates. The molecular biology of these transferases and other carbohydra- modifying enzymes is providing important insights on oligosaccharide recognition events.\nWhile it is acknowledged that the definition of the protein complement of cells and tissues (the so-called proteome) remains an enormous task in this postgenomic era, the characterization of all glycans produced by individual organisms (referred to as the glycome) presents an equally imp- tant challenge. This task is further complicated by the fact that oligosacc- rides cannot presently be cloned. These complex carbohydrates exist in a staggering diversity of structures, linkages, and branching, thus providing an exquisite molecular repertoire for cellular interactions.","brand":"Humana Press Inc.","offers":[{"title":"Default Title","offer_id":39668027916373,"sku":"9780896038264N","price":121.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2481\/5790\/products\/eb99f7bc-c885-4cbd-a9a1-eac9c2593ef4.jpg?v=1644269981","url":"https:\/\/smeikalbooks.co.uk\/en-us\/products\/capillary-electrophoresis-of-carbohydrates-213-methods-in-molecular-biology","provider":"smeikalbooks","version":"1.0","type":"link"}